People who have survived breast cancer face a higher risk of developing chronic diseases and experiencing recurrence. Although a healthy diet is commonly recommended as a preventive measure, there is still a lack of clinical studies that thoroughly analyse the relationship between nutrition and the development of other health problems after cancer survival. Advances in omics technologies offer new opportunities to personalise nutrition and reduce these risks more effectively.
AZTI and Onkologikoa conducted a clinical trial involving 50 women who were breast cancer survivors, with the aim of assessing the benefits of personalised nutritional counselling on metabolic status, nutritional health and gut health.
The intervention was based on the analysis of individual metabolic and genetic profiles using omics technologies, complemented by questionnaires on dietary habits. In addition, gut microbiota was monitored throughout the study to evaluate the impact of the intervention on digestive health.
The personalised nutritional intervention based on lipidomic and nutrigenetic profiles proved more effective than a standard Mediterranean diet in improving cardiometabolic risk factors, body composition and quality of life in breast cancer survivors.
Improved quality of life, with a reduction in common symptoms such as fatigue, joint pain and sensitivity.
An average reduction of 1.8 kg of body fat over 12 months.
Reduced inflammation, contributing to a lower cardiovascular risk.
Improved nutritional status, with increases in key micronutrients such as iron, vitamin B12 and vitamin D.
The study also showed high adherence among participants, with very few dropouts. The women rated the nutritional programme very positively, highlighting increased confidence, motivation and their willingness to recommend it to others in similar situations.
Sectors: Food and Health
Research lines: Healthy ageing, Personalised nutrition and health
Research sublines: Precision nutrition technologies, The impact of food on human health